Intravesical liposome and antisense treatment for detrusor overactivity and interstitial cystitis/painful bladder syndrome.

Abstract

Purpose. The following review focuses on the recent advancements in intravesical drug delivery, which brings added benefit to the therapy of detrusor overactivity and interstitial cystitis/painful bladder syndrome (IC/PBS). Results. Intravesical route is a preferred route of administration for restricting the action of extremely potent drugs like DMSO for patients of interstitial cystitis/painful bladder syndrome (IC/PBS) and botulinum toxin for detrusor overactivity. Patients who are either refractory to oral treatment or need to mitigate the adverse effects encountered with conventional routes of administration also chose this route. Its usefulness in some cases can be limited by vehicle (carrier) toxicity or short duration of action. Efforts have been underway to overcome these limitations by developing liposome platform for intravesical delivery of biotechnological products including antisense oligonucleotides. Conclusions. Adoption of forward-thinking approaches can achieve advancements in drug delivery systems targeted to future improvement in pharmacotherapy of bladder diseases. Latest developments in the field of nanotechnology can bring this mode of therapy from second line of treatment for refractory cases to the forefront of disease management.

• Authors: Pradeep Tyagi, Mahendra P Kashyap, Naoki Kawamorita, Tsuyoshi Yoshizawa, Michael Chancellor, Naoki Yoshimura
• Journal: ISRN pharmacology (ISRN Pharmacol) Vol. 2014 Pg. 601653 ( 2014) ISSN: 2090-5165 [Print] Egypt
• PMID: 24527221 (Publication Type: Journal Article, Review)