Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease.

Abstract

IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

• Authors: N Latov, A P Hays, P D Donofrio, J Liao, H Ito, S McGinnis, M Konstadoulakis, L Freddo, M E Shy, K Manoussos
• Journal: Neurology (Neurology) Vol. 38 Issue 5 Pg. 763-8 (May 1988) ISSN: 0028-3878 [Print] United States
• PMID: 2452383 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Monoclonal
• Autoantibodies
• Epitopes
• Gangliosides
• Immunoglobulin M
• Oligosaccharides
• ganglioside, GD1b
• G(M1) Ganglioside
• lacto-N-neotetraose

Topics

• Antibodies, Monoclonal (immunology)
• Autoantibodies (immunology)
• Epitopes
• Female
• Fluorescent Antibody Technique
• G(M1) Ganglioside (immunology)
• Gangliosides (immunology)
• Humans
• Immunoglobulin M (immunology)
• Male
• Middle Aged
• Motor Neurons
• Nerve Tissue (immunology)
• Neuromuscular Diseases (enzymology)
• Oligosaccharides (immunology)