Abstract | PURPOSE: We sought to determine the effect of sildenafil on retinal vascular changes in a mouse model of oxygen-induced retinopathy (OIR). METHODS: RESULTS: At P12, OIR mice treated with sildenafil demonstrated a 24% reduction in vaso-obliteration (P < 0.05), whereas at P17, treated animals showed a 50% reduction in neovascularization (P < 0.05) compared to dextrose-treated controls. Sildenafil-treated OIR mice had stabilization of retinal HIF1α at P12, immediately after hyperoxia. At P17, sildenafil-treated OIR mice had decreased HIF1α relative to untreated mice. OIR mice developed right ventricle hypertrophy that was significant compared to that in room air controls, which was abrogated by sildenafil. CONCLUSIONS:
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Authors | Amani A Fawzi, Jonathan C Chou, Gina A Kim, Stuart D Rollins, Joann M Taylor, Kathryn N Farrow |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 55
Issue 3
Pg. 1493-501
(Mar 10 2014)
ISSN: 1552-5783 [Electronic] United States |
PMID | 24519428
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Piperazines
- Purines
- Sulfones
- Vasodilator Agents
- Sildenafil Citrate
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Topics |
- Animals
- Disease Models, Animal
- Mice
- Mice, Inbred C57BL
- Piperazines
(pharmacology)
- Purines
(pharmacology)
- Retinal Neovascularization
(drug therapy, etiology, pathology)
- Retinal Vessels
(drug effects, pathology, physiopathology)
- Retinopathy of Prematurity
(complications, drug therapy, pathology)
- Sildenafil Citrate
- Sulfones
(pharmacology)
- Vasoconstriction
(drug effects)
- Vasodilator Agents
(pharmacology)
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