Abstract | OBJECTIVE: The present study aimed to investigate the mechanisms underlying the anti-inflammatory and anti-angiogenic effects of ethyl-p-methoxycinnamate isolated from Kaempferia galanga. METHODS: RESULTS: CONCLUSION:
Ethyl-p-methoxycinnamate exhibits significant anti-inflammatory potential by inhibiting pro-inflammatory cytokines and angiogenesis, thus inhibiting the main functions of endothelial cells. Thus, ethyl-p-methoxycinnamate could be a promising therapeutic agent for the treatment of inflammatory and angiogenesis-related diseases.
|
Authors | Muhammad Ihtisham Umar, Mohd Zaini Asmawi, Amirin Sadikun, Amin Malik Shah Abdul Majid, Fouad Saleih R Al-Suede, Loiy Elsir Ahmed Hassan, Rabia Altaf, Mohamed B Khadeer Ahamed |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 69
Issue 2
Pg. 134-44
(Feb 2014)
ISSN: 1980-5322 [Electronic] United States |
PMID | 24519205
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Angiogenesis Inhibitors
- Anti-Inflammatory Agents
- Cinnamates
- Interleukin-1
- Plant Extracts
- Tumor Necrosis Factor-alpha
- Vascular Endothelial Growth Factor A
- ethyl 4-methoxycinnamate
|
Topics |
- Analysis of Variance
- Angiogenesis Inhibitors
(isolation & purification, pharmacology)
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology)
- Cell Proliferation
(drug effects)
- Cinnamates
(pharmacology)
- Enzyme-Linked Immunosorbent Assay
- Human Umbilical Vein Endothelial Cells
(drug effects)
- Humans
- Interleukin-1
(analysis)
- Male
- Plant Extracts
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reproducibility of Results
- Tumor Necrosis Factor-alpha
(analysis, drug effects)
- U937 Cells
(drug effects)
- Vascular Endothelial Growth Factor A
(analysis, drug effects)
- Zingiberaceae
(chemistry)
|