Statin-associated necrotizing autoimmune myopathy.

Abstract

Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies.

• Authors: Geórgea Hermogenes Fernandes, Edmar Zanoteli, Samuel Katsuyuki Shinjo
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 24 Issue 5 Pg. 862-4 (Sep 2014) ISSN: 1439-7609 [Electronic] England
• PMID: 24517559 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Topics

• Aged
• Autoimmune Diseases (chemically induced, pathology)
• Female
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use)
• Hypercholesterolemia (drug therapy)
• Muscle, Skeletal (pathology)
• Muscular Diseases (chemically induced, pathology)