AIDS-related lymphoma: resolution with antiretroviral therapy alone.

Abstract

Patients with HIV are at increased risk of malignancy, particularly lymphoma, which is the most common malignancy leading to death. With the advent of highly active antiretroviral therapy (HAART), patients live longer but have a longer duration of antigenic stimulation, increasing the prevalence of AIDS-related lymphoma (ARL) in the population living with HIV. Highly active antiretroviral therapy plays a direct role in preserving the immune system, helping to decrease the incidence of ARL. We present a case of a female patient with HIV (CD4 count of 576 cells/mm3) diagnosed with a stage Ill-B non-Hodgkin lymphoma in 2009 while off HAART. She was subsequently started on HAART, leading to full resolution of her lymphoma without any chemotherapeutic intervention. She was last seen in the clinic in December 2013 without any evidence of recurrence of her lymphoma. To our knowledge, this is the first case report of a stage III-B non-Hodgkin<in lymphoma in an HIV-infected patient, which resolved with only HAART.

• Authors: Rabih Riad Hallit, Muhammad Afridi, Raymund Sison, Maria Elaine Y Szabela, Nikki Bajaj, Roula Alchaa, Souheil Hallit, Nelly Awkar, Jack Boghossian, Jihad Slim
• Journal: Journal of the International Association of Providers of AIDS Care (J Int Assoc Provid AIDS Care) 2014 Jul-Aug Vol. 13 Issue 4 Pg. 313-5 ISSN: 2325-9574 [Print] United States
• PMID: 24515400 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• Dideoxynucleosides
• HIV Protease Inhibitors
• Sulfonamides
• Lamivudine
• Ritonavir
• abacavir
• Darunavir

Topics

• Anti-HIV Agents (therapeutic use)
• Antiretroviral Therapy, Highly Active
• Darunavir
• Dideoxynucleosides (therapeutic use)
• Female
• HIV Protease Inhibitors (therapeutic use)
• Humans
• Lamivudine (therapeutic use)
• Lymphoma, AIDS-Related (drug therapy, pathology)
• Middle Aged
• Ritonavir (therapeutic use)
• Sulfonamides (therapeutic use)