Abstract |
GABAergic neurons are known to inhibit neural transduction and therefore negatively affect excitatory neural circuits in the brain. We have previously reported that 5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one (AC-3933), a partial inverse agonist for the benzodiazepine receptor (BzR), reverses GABAergic inhibitory effect on cholinergic neurons, and thus enhances acetylcholine release from these neurons in rat hippocampal slices. In this study, we evaluated AC-3933 potential for the treatment of Alzheimer's disease, a disorder characterized by progressive decline mainly in cholinergic function. Oral administration of AC-3933 (0.01-0.03mg/kg) resulted in the amelioration of scopolamine-induced amnesia, as well as a shift in electroencephalogram (EEG) relative power characteristic of pro-cognitive cholinergic activators, such as donepezil. In addition, treatment with AC-3933 even at the high dose of 100mg/kg p.o. produced no seizure or anxiety, two major adverse effects of BzR inverse agonists developed in the past. These findings indicate that AC-3933 with its low risk for side effects may be useful in the treatment of Alzheimer's disease.
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Authors | Y Hatayama, T Hashimoto, H Kohayakawa, T Kiyoshi, K Nakamichi, T Kinoshita, N Yoshida |
Journal | Neuroscience
(Neuroscience)
Vol. 265
Pg. 217-25
(Apr 18 2014)
ISSN: 1873-7544 [Electronic] United States |
PMID | 24513386
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- 5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine
- GABA-A Receptor Antagonists
- Naphthyridines
- Oxadiazoles
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Topics |
- Alzheimer Disease
(drug therapy)
- Amnesia
(drug therapy)
- Animals
- Brain
(drug effects, physiology)
- Drug Inverse Agonism
- Electroencephalography
- GABA-A Receptor Antagonists
(administration & dosage, therapeutic use)
- Male
- Mice
- Naphthyridines
(administration & dosage, adverse effects, therapeutic use)
- Oxadiazoles
(administration & dosage, adverse effects, therapeutic use)
- Rats
- Rats, Wistar
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