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Synthesis of carboxymethyl chitosan and coating on wound dressing gauze for wound healing.

Abstract
Wound healing is a long and complex process. To improve wound healing, the wound dressing cotton gauze can be functionalized by imparting moisture holding and antibacterial ability. Moisture is an important factor for wound healing and the absence of microbial intervention can accelerate wound healing process. Direct alkylation method was used to synthesis carboxymethylated chitosan with water solubility, biocompatibility and antibacterial activity. Calcium alginate was used along with modified chitosan as moisture gaining polymeric agent. Pad-dry-cure method was employed to coat both the polymers on cotton gauze surface, which was weaved using 40s Ne cotton yarn. After coating, the cotton was analysed for its polymer add-on percentage, antibacterial action against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10229. The persistence analysis of antibacterial activity ensures the polymer withstanding ability on cotton gauze surface. SEM detection of polymers with cotton threads confirms their presence. Wound healing action of the polymer coated cotton gauze was determined using albino rats as animal model.
AuthorsB Venkatrajah, V Vanitha Malathy, B Elayarajah, R Rajendran, Ram Rammohan
JournalPakistan journal of biological sciences : PJBS (Pak J Biol Sci) Vol. 16 Issue 22 Pg. 1438-48 (Nov 15 2013) ISSN: 1028-8880 [Print] Pakistan
PMID24511685 (Publication Type: Journal Article)
Chemical References
  • Alginates
  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Hexuronic Acids
  • carboxymethyl-chitosan
  • Water
  • Glucuronic Acid
  • Chitosan
Topics
  • Alginates (chemistry)
  • Animals
  • Anti-Bacterial Agents (administration & dosage, chemical synthesis, pharmacology)
  • Bandages
  • Chitosan (administration & dosage, analogs & derivatives, chemical synthesis, pharmacology)
  • Coated Materials, Biocompatible
  • Cotton Fiber
  • Escherichia coli (drug effects, growth & development)
  • Female
  • Glucuronic Acid (chemistry)
  • Hexuronic Acids (chemistry)
  • Microscopy, Electron, Scanning
  • Models, Animal
  • Rats
  • Solubility
  • Staphylococcus aureus (drug effects, growth & development)
  • Time Factors
  • Water (chemistry)
  • Wound Healing (drug effects)

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