Managing young colorectal cancer: a UK and Irish perspective.

Abstract

OBJECTIVE:

Young patients with familial syndromes have an increased metachronous cancer rate. Effective management is possible by identifying this high-risk group prior to index colectomy. The study surveys the Association of Coloproctology of Great Britain and Ireland (ACPGBI) membership preoperative evaluation and clinical management in young patients with colorectal cancer (CRC).

METHOD:

An electronic survey was sent to the membership of the ACPGBI. The survey polled members on clinical scenarios relating to young-onset CRC patients. We were particularly concerned with preoperative management strategies, the extent of colectomy, and postoperative surveillance. Survey responses were collated and analysed.

RESULTS:

A total of 124 members responded to the survey and 74 completed the survey. Of these, 87.8 % would proceed to colectomy without preoperative tumor or genetic testing. Decisions regarding the extent of colectomy depended on family history. A total of 67 (90.6 %) would offer a limited colectomy with no family history, 49 (66.2 %) in a patient with familial CRC type X, 29 (39.2 %) in a young patient with Lynch syndrome. A similar trend was seen with young rectal cancer. Only 16 surgeons (21.6 %) could identify a syndrome of MYH-associated polyposis (MAP).

CONCLUSION:

The majority of ACPGBI members will not offer preoperative risk testing based on a young age alone; however, the majority would alter their surgical strategy based on the results of this testing. MAP is poorly recognized by ACPGBI members and therefore an opportunity exists for education among members. WHAT IS NEW IN THIS PAPER?: This study is the first paper to survey the ACPGBI membership on management practices in young-onset CRC. Members are poor in adopting preoperative testing, alter surgical strategy based on a familial syndrome, with a minority recognizing MAP. An opportunity to improve education on young CRC patients exists.

• Authors: Satish K Warrier, Justin M Yeung, A Craig Lynch, Alexander G Heriot
• Journal: World journal of surgery (World J Surg) Vol. 38 Issue 7 Pg. 1827-33 (Jul 2014) ISSN: 1432-2323 [Electronic] United States
• PMID: 24510247 (Publication Type: Journal Article)

Topics

• Adenomatous Polyposis Coli (chemistry, genetics, surgery)
• Adult
• Colectomy (methods)
• Colonic Neoplasms (chemistry, genetics, surgery)
• Colorectal Neoplasms, Hereditary Nonpolyposis (chemistry, genetics, surgery)
• DNA Mismatch Repair
• Female
• Genetic Testing
• Health Care Surveys
• Health Knowledge, Attitudes, Practice
• Humans
• Immunohistochemistry
• Ireland
• Male
• Microsatellite Instability
• Population Surveillance
• Practice Patterns, Physicians' (statistics & numerical data)
• Preoperative Care
• Rectal Neoplasms (chemistry, genetics, surgery)
• United Kingdom