Abstract | BACKGROUND:
Melamine was recently identified as a risk factor for renal calculi following the milk powder contamination in China. However, the long-term natural history of melamine exposure and its renal effects remain unknown. We evaluated renal function and other adverse health effects using a rat model administered melamine and cyanuric aid, considering age and sex. METHODS: Twelve male F334/N rats each of ages 6, 10, and 26 weeks (N = 36) were equally assigned to Group M + C or controls. Group M + C rats were administered 12 mg · kg(-1) · day(-1) of melamine and cyanuric acid for 28 days. Serum and urine samples and kidney sections were evaluated on day 28. Six-week-old male and female F344/N rats were administered 12 mg of melamine and cyanuric acid for 28 days. Body weights were measured weekly; on days 0, 28, 90, and 180 after the 28-day period of melamine and cyanuric acid administration, serum samples and kidney sections were obtained. RESULTS: Although the control group had no crystals, 6-week-old Group M + C rats had more crystals compared to the 10- and 26-week old Group M + C rats. Male rats also had significantly more crystals than females of the same age. Male rats were affected to a greater extent than females. CONCLUSION:
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Authors | Takahiro Yasui, Takahiro Kobayashi, Atsushi Okada, Shuzo Hamamoto, Masahito Hirose, Kentaro Mizuno, Yasue Kubota, Yukihiro Umemoto, Noriyasu Kawai, Keiichi Tozawa, Bing Gao, Kenjiro Kohri |
Journal | BMC research notes
(BMC Res Notes)
Vol. 7
Pg. 87
(Feb 08 2014)
ISSN: 1756-0500 [Electronic] England |
PMID | 24507656
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Triazines
- Creatinine
- cyanuric acid
- melamine
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Topics |
- Age Factors
- Animals
- Blood Urea Nitrogen
- Creatinine
(blood)
- Crystallization
- Drug Synergism
- Early Diagnosis
- Female
- Growth Disorders
(chemically induced, pathology)
- Kidney Calculi
(blood, chemically induced, pathology, urine)
- Male
- Rats
- Rats, Inbred F344
- Renal Insufficiency
(blood, chemically induced, pathology, urine)
- Triazines
(administration & dosage, toxicity)
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