Abstract | BACKGROUND: METHODS: We conducted a meta-analysis of RCTs performed in adults with ADPKD, and compared the effect of sirolimus on total kidney volume (TKV), glomerular filtration rate (GFR), cyst volume, and daily urinary protein excretion. Safety was evaluated based on analysis of blood pressure, lipid profile, complete blood count, infection, and other reported adverse events. RESULTS: Four RCTs were included. The sirolimus therapy group had smaller TKV than the control group. The mean difference (MD) of TKV post-treatment compared with the control group was -234.74 (P = .01). However, GFR did not reach a statistically significant difference between groups. Standard mean difference (SMD) of GFR after therapy was 0.24 (95% confidence interval [CI], 0.05-0.52; P = .11), but sirolimus seemed to increase urine protein excretion (P = .002). There was no statically significant difference in leukocytes, hemoglobin, platelets, and blood pressure between groups. Aphthous stomatits and pharyngitis are reported more commonly in the sirolimus therapy group compared with the control group (P < .000001). CONCLUSIONS: In ADPKD patients, treatment with sirolimus is safe and can effectively slow kidney growth, but it seems not to slow down the decrease of GFR.
|
Authors | Y-M Liu, Y Q Shao, Q He |
Journal | Transplantation proceedings
(Transplant Proc)
2014 Jan-Feb
Vol. 46
Issue 1
Pg. 66-74
ISSN: 1873-2623 [Electronic] United States |
PMID | 24507028
(Publication Type: Journal Article, Meta-Analysis)
|
Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Immunosuppressive Agents
- Sirolimus
|
Topics |
- Blood Pressure
- Glomerular Filtration Rate
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Kidney
(pathology)
- Pharyngitis
(etiology)
- Polycystic Kidney, Autosomal Dominant
(drug therapy)
- Proteinuria
(etiology)
- Randomized Controlled Trials as Topic
- Signal Transduction
- Sirolimus
(therapeutic use)
- Stomatitis
(etiology)
- Treatment Outcome
|