Abstract |
We have developed a general synthetic route to encapsulate small molecules in monodisperse zeolitic imid-azolate framework-8 (ZIF-8) nanospheres for drug delivery. Electron microscopy, powder X-ray diffraction, and elemental analysis show that the small-molecule-encapsulated ZIF-8 nanospheres are uniform 70 nm particles with single-crystalline structure. Several small molecules, including fluorescein and the anticancer drug camptothecin, were encapsulated inside of the ZIF-8 framework. Evaluation of fluorescein-encapsulated ZIF-8 nanospheres in the MCF-7 breast cancer cell line demonstrated cell internalization and minimal cytotoxicity. The 70 nm particle size facilitates cellular uptake, and the pH-responsive dissociation of the ZIF-8 framework likely results in endosomal release of the small-molecule cargo, thereby rendering the ZIF-8 scaffold an ideal drug delivery vehicle. To confirm this, we demonstrate that camptothecin encapsulated ZIF-8 particles show enhanced cell death, indicative of internalization and intracellular release of the drug. To demonstrate the versatility of this ZIF-8 system, iron oxide nanoparticles were also encapsulated into the ZIF-8 nanospheres, thereby endowing magnetic features to these nanospheres.
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Authors | Jia Zhuang, Chun-Hong Kuo, Lien-Yang Chou, De-Yu Liu, Eranthie Weerapana, Chia-Kuang Tsung |
Journal | ACS nano
(ACS Nano)
Vol. 8
Issue 3
Pg. 2812-9
(Mar 25 2014)
ISSN: 1936-086X [Electronic] United States |
PMID | 24506773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Capsules
- Cetrimonium Compounds
- Drug Carriers
- Imidazoles
- Organometallic Compounds
- Cetrimonium
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Topics |
- Capsules
- Cell Survival
(drug effects)
- Cetrimonium
- Cetrimonium Compounds
(chemistry)
- Drug Carriers
(chemistry, toxicity)
- Humans
- Imidazoles
(chemistry)
- MCF-7 Cells
- Models, Molecular
- Molecular Conformation
- Nanospheres
(chemistry, toxicity)
- Organometallic Compounds
(chemistry, toxicity)
- Particle Size
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