Platinum doublets as first-line treatment for elderly patients with advanced non-small cell lung cancer.

Abstract

AIMS AND BACKGROUND:

More than 50% of patients with advanced non-small cell lung cancer are diagnosed in the elderly. Few prospective clinical data with cisplatin-based chemotherapy are available, and some authors have suggested that a non-platinum single agent should be the preferred form of cure in these patients. The aim of the study was to evaluate the efficacy and safety of first-line chemotherapy based on platinums (carboplatin or cisplatin) plus a third generation compound (vinorelbine or gemcitabine) in elderly patients with advanced non-small cell lung cancer in daily clinical practice.

METHODS:

A retrospective analysis of consecutive elderly (≥70 years of age) patients with advanced non-small cell lung cancer treated at our Medical Oncology Unit from February 2005 to September 2011 was performed.

RESULTS:

A total of 249 cycles of chemotherapy was administered to 62 patients (median age, 72 years; range, 70-81) presenting a median Charlson comorbidity index of 1 and a good ECOG PS (0-1, 52 patients; 2, 10 patients). The median number of cycles/patient was 4, and all 62 patients received a platinum-based doublet as first-line chemotherapy: 57 with carboplatin (92%) and 5 with cisplatin (8%). As best response to the treatment, 19 (31%) partial responses and 20 (32%) stable diseases were observed. Median overall survival was 9.8 months. Toxicity was mild; grade III-IV neutropenia was the most frequently observed side effect in 19 administered cycles (8%).

CONCLUSIONS:

Advanced non-small cell lung cancer in elderly patients can be safely treated with a platinum-based doublet. Observed toxicity is manageable, and overall survival is in keeping with data from the literature.

• Authors: Paolo Piacentini, Filippo Greco, Anna Mercanti, Anna Rita Trolese, Emilia Durante, Giacomo Moratello, Michele Tognetto, Lara Furini, Jacopo Giuliani, Andrea Bonetti
• Journal: Tumori (Tumori) 2013 Nov-Dec Vol. 99 Issue 6 Pg. 650-5 ISSN: 2038-2529 [Electronic] United States
• PMID: 24503786 (Publication Type: Journal Article)

Chemical References

• Deoxycytidine
• Vinblastine
• Carboplatin
• Cisplatin
• Vinorelbine
• Gemcitabine

Topics

• Adenocarcinoma (drug therapy)
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Carcinoma, Squamous Cell (drug therapy)
• Cisplatin (administration & dosage)
• Comorbidity
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Disease-Free Survival
• Drug Administration Schedule
• Female
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (drug therapy, pathology)
• Male
• Neoplasm Staging
• Retrospective Studies
• Treatment Outcome
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine
• Gemcitabine