[Impact of L-arginin immobilized on surgical suture material on the oxidation metabolism in the periwound tissues of the operated small bowel].

Abstract

In experiment on 50 white rats of the Wistar line there was investigated the impact of L-arginin, while its systemic and local (in a content of synthetic absorbable suture material) application, on the indices of a free-radical and bioenergetics processes in a small bowel tissues after experimental enterotomy. There was shown, that as a consequence of L-arginin application there in periwound tissues of a small bowel on the third postoperative day the superoxidal anion-radical production and the processes of peroxidal oxidation of lipids (POL) go down, what prophylaxes the antioxidant potential lowering and a content of the macroergic complexes and energetic potential enhancement. The investigation results witness, that the L-arginin efficacy substantiates the need for creation of a new pharmacologically modified synthetic suture material, which prophylaxes the free-radical and hypoxic necrobiosis and stimulates healing processes in a surgical wound.

• Authors: T H Dikhtenko, A A Levkov, V O Kostenko
• Journal: Klinichna khirurhiia (Klin Khir) Issue 9 Pg. 66-9 (Sep 2013) ISSN: 0023-2130 [Print] Ukraine
• PMID: 24501934 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adenine Nucleotides
• Antioxidants
• Arginine

Topics

• Adenine Nucleotides (metabolism)
• Animals
• Antioxidants (pharmacology)
• Arginine (pharmacology)
• Intestine, Small (metabolism, surgery)
• Oxidative Stress (drug effects)
• Rats
• Rats, Wistar
• Sutures
• Wound Healing (drug effects)