The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis.

Abstract

The aim of this study was to evaluate the diagnostic value of anti-mitochondrial antibodies (AMAs) and/or the M2 subtype (AMA-M2) in patients with primary biliary cirrhosis (PBC). AMA/AMA-M2 data were obtained by searching electronic databases. Studies showing AMA/AMA-M2 results in patients with PBC and control groups with other liver diseases or healthy livers were included. The quality of the involved studies was assessed using the QUADAS tool. The pooled sensitivity and specificity were calculated, and stratified analysis was performed according to possible heterogeneity sources. The pooled AMA (all methods) sensitivity and specificity were 84.5% (95% confidence interval (CI) 83.3%-85.6%) and 97.8% (95% CI 97.6%-98.0%), respectively. The positive and negative likelihood ratios were 25.201 (95% CI 17.583-36.118) and 0.162 (95% CI 0.131-0.199), respectively. The current evidence suggests that AMA and AMA-M2 show favorable accuracy for the diagnosis of PBC with high specificity and sensitivity. AMA is a better and more comprehensive marker than AMA-M2. The accuracy established in this meta-analysis is based on clinical studies using patient cohorts from different ethnicities.

• Authors: Shiling Hu, Fengrong Zhao, Qingsong Wang, Wei-Xian Chen
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 52 Issue 11 Pg. 1533-42 (Nov 2014) ISSN: 1437-4331 [Electronic] Germany
• PMID: 24501161 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Autoantibodies

Topics

• Autoantibodies (analysis, immunology)
• Blotting, Western
• Databases, Factual
• Enzyme-Linked Immunosorbent Assay
• Fluorescent Antibody Technique, Indirect
• Humans
• Liver Cirrhosis, Biliary (diagnosis)
• Mitochondria (immunology)
• ROC Curve