No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.

Abstract

Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubation with the maximum tolerated dose for 6 weeks. Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange.

• Authors: K T Cain, C V Cornett, N L Cacheiro, L A Hughes, J G Owens, W M Generoso
• Journal: Environmental and molecular mutagenesis (Environ Mol Mutagen) Vol. 11 Issue 2 Pg. 207-13 ( 1988) ISSN: 0893-6692 [Print] United States
• PMID: 2450017 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Cyclamates

Topics

• Animals
• Chromosome Aberrations
• Cyclamates (pharmacology, toxicity)
• Genes, Dominant (drug effects)
• Genes, Lethal (drug effects)
• Male
• Mice
• Mice, Inbred C3H
• Mice, Inbred C57BL
• Translocation, Genetic (drug effects)