Abstract |
Although considerable progress has been made in understanding how tumors evade immune surveillance, measures to counter the same have not kept pace with the advances made in designing effective strategies. 4-1BB (CD137; TNFRS9), an activation-induced costimulatory molecule, is an important regulator of immune responses. Targeting 4-1BB or its natural ligand 4-1BB ligand (4-1BBL) has important implications in many clinical conditions, including cancer. In depth analysis revealed that 4-1BB-mediated anti- cancer effects are based on its ability to induce activation of cytotoxic T lymphocytes (CTL), and among others, high amounts of IFN-γ. In this review, we will discuss the various aspects of 4-1BB-mediated anti- tumor responses, the basis of such responses, and future directions.
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Authors | Dass S Vinay, Byoung S Kwon |
Journal | BMB reports
(BMB Rep)
Vol. 47
Issue 3
Pg. 122-9
(Mar 2014)
ISSN: 1976-670X [Electronic] Korea (South) |
PMID | 24499671
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antineoplastic Agents
- Tumor Necrosis Factor Receptor Superfamily, Member 9
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Humans
- Molecular Targeted Therapy
- Neoplasms
(blood, drug therapy, pathology)
- Phenotype
- Signal Transduction
(drug effects)
- Tumor Necrosis Factor Receptor Superfamily, Member 9
(metabolism)
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