HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis.

Abstract
Feline lymphocytic cholangitis (LC) has been commonly treated with prednisolone, and more recently with ursodeoxycholic acid (UDCA). Previously, we found that prednisolone treatment resulted in a statistically longer survival time than treatment with UDCA. In order to explain this difference, we compared the effects of prednisolone and UDCA treatment on hepatic tissue by evaluating consecutive liver biopsies. Archival serial biopsy materials from cats with LC treated with prednisolone (n = 5) or UDCA (n = 4) were evaluated. We employed haematoxylin and eosin staining to evaluate inflammation, and reticulin staining for fibrosis. Immunohistochemical stainings for Ki-67, K19 (Cytokeratin 19) and α-smooth muscle actin were used to evaluate cell type-specific proliferation and activation of hepatic stellate cells. Inflammation decreased more in the group treated with prednisolone, while the number of cholangiocytes, progenitor cells and fibroblasts did not differ between the treatment groups. Additionally, no difference was found for the amount of fibrosis in both treatment groups.
AuthorsCorma Ma Otte, Jan Rothuizen, Robert P Favier, Louis C Penning, Sandra Vreman
JournalJournal of feline medicine and surgery (J Feline Med Surg) Vol. 16 Issue 10 Pg. 796-804 (Oct 2014) ISSN: 1532-2750 [Electronic] England
PMID24496321 (Publication Type: Comparative Study, Journal Article)
Copyright© ISFM and AAFP 2014.
Chemical References
  • Ursodeoxycholic Acid
  • Prednisolone
Topics
  • Animals
  • Biopsy
  • Cat Diseases (drug therapy, pathology)
  • Cats
  • Cell Proliferation (drug effects)
  • Cholangitis (drug therapy, pathology, veterinary)
  • Female
  • Immunohistochemistry
  • Liver (drug effects, pathology)
  • Lymphocytes (drug effects, pathology)
  • Male
  • Prednisolone (pharmacology, therapeutic use)
  • Ursodeoxycholic Acid (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: