Abstract | BACKGROUND: METHODS: A retrospective review was conducted of trauma patients treated with intrapleural tPA for retained hemothorax. Data included demographics, past medical and surgical histories, injury details, treatment details, and outcomes. RESULTS: Seven patients (median age = 47 years, male = 6, blunt trauma = 6) met study criteria. All patients received a chest tube. Six patients later received computed tomography-guided drains for tPA infusion. Number of tPA treatments per patient varied from 1 to 5. Median total tPA dosage was 24 mg. Median time from injury to chest tube placement was 11 days and from chest tube placement to first tPA treatment was 4 days. No patients required a video-assisted thoracoscopy; however, 1 patient required thoracotomy. There were no deaths or bleeding complications attributed to intrapleural tPA. CONCLUSION: Although future studies are needed to identify optimum treatment guidelines, intrapleural tPA appears to be a safe and efficacious treatment option.
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Authors | P J Stiles, Rachel M Drake, Stephen D Helmer, Paul M Bjordahl, James M Haan |
Journal | American journal of surgery
(Am J Surg)
Vol. 207
Issue 6
Pg. 960-3
(Jun 2014)
ISSN: 1879-1883 [Electronic] United States |
PMID | 24495319
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Fibrinolytic Agents
- Tissue Plasminogen Activator
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Chest Tubes
- Comorbidity
- Female
- Fibrinolytic Agents
(administration & dosage)
- Hemothorax
(drug therapy, etiology)
- Humans
- Male
- Middle Aged
- Radiography, Interventional
- Retrospective Studies
- Risk Factors
- Thoracic Injuries
(complications, surgery)
- Thoracic Surgery, Video-Assisted
- Thoracotomy
- Tissue Plasminogen Activator
(administration & dosage)
- Tomography, X-Ray Computed
- Treatment Outcome
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