The effect of bumetanide treatment on the sensory behaviours of a young girl with Asperger syndrome.

Abstract

Sensory behaviours were not considered as core features of autism spectrum disorders until recently. However, they constitute an important part of the observed symptoms that result in social maladjustment and are currently quite difficult to treat. One promising strategy for the treatment of these behaviours is the use of bumetanide, which was previously shown to reduce the severity of autism spectrum disorders. In this study, we proposed to evaluate sensory behaviours using Dunn's Sensory Profile after 18 months of bumetanide treatment in a 10-year-old girl with Asperger syndrome. Reported improvements covered a large range of sensory behaviours, including auditory, vestibular, tactile, multisensory and oral sensory processing. Although our results were limited to a single case report, we believe that our clinical observations warrant clinical trials to test the long-term efficacy of bumetanide to manage the sensory behaviours of people with autism spectrum disorders.

• Authors: Marine Grandgeorge, Eric Lemonnier, Céline Degrez, Nelle Jallot
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2014 (Jan 31 2014) ISSN: 1757-790X [Electronic] England
• PMID: 24488662 (Publication Type: Case Reports, Journal Article)

Chemical References

• Sodium Potassium Chloride Symporter Inhibitors
• Bumetanide

Topics

• Asperger Syndrome (drug therapy)
• Bumetanide (therapeutic use)
• Child
• Female
• Humans
• Sodium Potassium Chloride Symporter Inhibitors (therapeutic use)
• Treatment Outcome