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Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis.

Abstract
Lipoprotein glomerulopathy is an inherited renal disease characterized by unique lipoprotein thrombi in the glomerulus and is associated with the APOE mutation. Hu and colleagues investigated the genetic and clinical features of a large group of patients with lipoprotein glomerulopathy who carried APOE Kyoto, a major APOE variant. Their findings suggest its descent through a founder effect. Fibrate therapy in this group showed favorable results in the patient and renal survival rates.
AuthorsTakao Saito, Akira Matsunaga
JournalKidney international (Kidney Int) Vol. 85 Issue 2 Pg. 243-5 (Feb 2014) ISSN: 1523-1755 [Electronic] United States
PMID24487366 (Publication Type: Journal Article, Comment)
Chemical References
  • Apolipoprotein E2
  • Hypolipidemic Agents
  • apolipoprotein E2 (Kyoto)
  • Fenofibrate
Topics
  • Apolipoprotein E2 (genetics)
  • Female
  • Fenofibrate (therapeutic use)
  • Humans
  • Hypolipidemic Agents (therapeutic use)
  • Kidney (drug effects)
  • Kidney Diseases (drug therapy, genetics)
  • Male
  • Mutation

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