Structural optimization of indole based compounds for highly promising anti-cancer activities: structure activity relationship studies and identification of lead molecules.

Abstract

Based on the anti-cancer data of previous compounds, 27 more compounds were synthesized and subjected to anti-cancer screening. Compounds were tested over 60 human tumor cell lines of different types of cancer. As per the data available, some compounds exhibited appreciable anti-cancer properties over certain cell lines with their GI₅₀ in nM range. With the help of UV-vis spectral studies, enzyme immunoassay and molecular modeling studies, dihydrofolate reductase was found to be the probable cellular target of the compounds under present investigation.

• Authors: Shaveta, Palwinder Singh
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 74 Pg. 440-50 (Mar 03 2014) ISSN: 1768-3254 [Electronic] France
• PMID: 24487192 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Indoles

Topics

• Antineoplastic Agents (chemistry, pharmacology)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Humans
• Indoles (chemistry, pharmacology)
• Magnetic Resonance Spectroscopy
• Molecular Docking Simulation
• Spectrometry, Mass, Electrospray Ionization
• Spectrophotometry, Infrared
• Spectrophotometry, Ultraviolet
• Structure-Activity Relationship