Abstract |
Based on the anti- cancer data of previous compounds, 27 more compounds were synthesized and subjected to anti- cancer screening. Compounds were tested over 60 human tumor cell lines of different types of cancer. As per the data available, some compounds exhibited appreciable anti- cancer properties over certain cell lines with their GI₅₀ in nM range. With the help of UV-vis spectral studies, enzyme immunoassay and molecular modeling studies, dihydrofolate reductase was found to be the probable cellular target of the compounds under present investigation.
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Authors | Shaveta, Palwinder Singh |
Journal | European journal of medicinal chemistry
(Eur J Med Chem)
Vol. 74
Pg. 440-50
(Mar 03 2014)
ISSN: 1768-3254 [Electronic] France |
PMID | 24487192
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Indoles
|
Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Humans
- Indoles
(chemistry, pharmacology)
- Magnetic Resonance Spectroscopy
- Molecular Docking Simulation
- Spectrometry, Mass, Electrospray Ionization
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
- Structure-Activity Relationship
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