Abstract |
Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular endothelial growth factor, and poly (ADP-ribose) polymerase in a variety of tumor cells. Importantly, synthetic derivative of OA, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid ( CDDO), and its C-28 methyl ester ( CDDO-Me) and C28 imidazole ( CDDO-Im) have demonstrated potent antiangiogenic and antitumor activities in rodent cancer models. These agents are presently under evaluation in phase I studies in cancer patients. This review summarizes the diverse molecular targets of OA and its derivatives and also provides clear evidence on their promising potential in preclinical and clinical situations.
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Authors | Muthu K Shanmugam, Xiaoyun Dai, Alan Prem Kumar, Benny K H Tan, Gautam Sethi, Anupam Bishayee |
Journal | Cancer letters
(Cancer Lett)
Vol. 346
Issue 2
Pg. 206-16
(May 01 2014)
ISSN: 1872-7980 [Electronic] Ireland |
PMID | 24486850
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Triterpenes
- oleanonic acid
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Topics |
- Animals
- Clinical Trials, Phase I as Topic
- Humans
- Neoplasms
(drug therapy, prevention & control)
- Triterpenes
(chemistry, pharmacology, therapeutic use)
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