[CCAFU Recommendations 2013: Testicular germ cell cancer].

Abstract

INTRODUCTION:

The objective of this article is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of the germ cell tumours of the testis.

MATERIAL AND METHODS:

The multidisciplinary working party studied previous guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommendation.

RESULTS:

The initial work-up of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography). Inguinal orchidectomy is the first-line treatment allowing characterization of the histological type, local staging and identification of risk factors for micrometastases. The management of stage I tumours must be adapted to the risk by explaining to the patient the benefits/disadvantages of active treatment or watchful waiting as a function of the risk of relapse. Treatment options for stage 1 seminomas comprise : watchful waiting, chemotherapy (1 cycle of carboplatin) or para-aortic radiotherapy. Treatment options for stage 1 nonseminomatous germ cell tumours comprise : watchful waiting, chemotherapy (2 cycles of BEP) or staging retroperitoneal lymphadenectomy. The management of metastatic tumours essentially comprises chemotherapy with 3 or 4 cycles of BEP according to the prognostic group. Radiotherapy may be indicated in seminomas with lymph node metastasis < 3 cm. Review 3 to 4 weeks post-chemotherapy is essentially based on tumour marker assays and chest, abdomen and pelvis computed tomography. Surgical retroperitoneal lymph node dissection is indicated for all residual NSGCT masses > 1 cm and for persistent residual seminoma masses > 3 cm with (18)F-FDG PET-CT uptake.

CONCLUSIONS:

Germ cell tumours have an excellent survival rate based on precise initial staging, adapted and strictly defined treatment and close surveillance.

• Authors: X Durand, J Rigaud, C Avancès, P Camparo, A Fléchon, T Murez, P Sèbe, S Culine, F Iborra, N Mottet, P Coloby, M Soulié, Les membres du CCAFU
• Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (Prog Urol) Vol. 23 Suppl 2 Pg. S145-60 (Nov 2013) ISSN: 1166-7087 [Print] France
• Vernacular Title: Recommandations en onco-urologie 2013 du CCAFU : Tumeurs germinales du testicule.
• PMID: 24485289 (Publication Type: English Abstract, Journal Article, Practice Guideline)
• Copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Topics

• Decision Trees
• Humans
• Male
• Neoplasms, Germ Cell and Embryonal (diagnosis, therapy)
• Testicular Neoplasms (diagnosis, therapy)