ICAM-1 +469 A/G polymorphism and cancer risk: a meta-analysis involving 9375 subjects.

Abstract

BACKGROUND:

The ICAM-1 +469 A/G polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The present meta-analysis aimed to investigate the association between the ICAM-1 +469 A/G polymorphism and cancer risk.

METHODS:

We searched PubMed, Embase to identify studies that evaluated the association between the ICAM-1 +469 A/G polymorphism and cancer risk. Data were extracted and statistical analysis was performed by using the software Revman 5.1 and STATA 12.0.

RESULTS:

A total of 14 studies involving 9375 subjects were included. The results suggested that ICAM-1 +469 A/G polymorphism had no associated with cancer risk (OR=0.91, 95% CI: 0.76-1.08, P=0.27 for GG+AG vs. AA). Subgroup analysis by cancer type indicated the there was no associated between this polymorphism and breast cancer (OR=0.91, 95% CI: 0.72-1.15, P=0.43 for GG+AG vs. AA), but it was associated with decreased risk of colorectal cancer (OR=0.59, 95% CI: 0.41-0.85, P=0.005 for GG+AG vs. AA). Subgroup analysis by ethnicity revealed a decreased risk of cancer among Caucasians (OR=0.88, 95% CI: 0.78-0.99, P=0.03 for GG+AG vs.

AA) CONCLUSION:

The evidence from current meta-analysis doesn't support the ICAM-1 +469 A/G polymorphism as a risk factor for cancer. Further studies are needed to validate these findings.

• Authors: Ye Wang, Liuqun Jia, Yongchun Shen, Shujin Guo, Chun Wan, Ting Yang, Jing An, Lei Chen, Tao Wang, Fuqiang Wen
• Journal: International journal of clinical and experimental medicine (Int J Clin Exp Med) Vol. 7 Issue 1 Pg. 84-92 ( 2014) ISSN: 1940-5901 [Print] United States
• PMID: 24482692 (Publication Type: Journal Article)