Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.

Abstract	The structurally simple glycero- and sphingo-phospholipids, lysophosphatidic acid (LPA) and sphingosine-1-phosphate, serve as important receptor-active mediators that influence blood and vascular cell function and are positioned to influence the events that contribute to the progression and complications of atherosclerosis. Growing evidence from preclinical animal models has implicated LPA, LPA receptors, and key enzymes involved in LPA metabolism in pathophysiologic events that may underlie atherosclerotic vascular disease. These observations are supported by genetic analysis in humans implicating a lipid phosphate phosphatase as a novel risk factor for coronary artery disease. In this review, we summarize current understanding of LPA production, metabolism, and signaling as may be relevant for atherosclerotic and other vascular disease.
Authors	Susan S Smyth, Paul Mueller, Fanmuyi Yang, J Anthony Brandon, Andrew J Morris
Journal	Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 34 Issue 3 Pg. 479-86 (Mar 2014) ISSN: 1524-4636 [Electronic] United States
PMID	24482375 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References	Apolipoproteins E Lysophospholipids sphingosine 1-phosphate lipid phosphate phosphatase PLPP3 protein, human Phosphatidate Phosphatase Plpp3 protein, mouse Phosphoric Diester Hydrolases alkylglycerophosphoethanolamine phosphodiesterase Sphingosine lysophosphatidic acid
Topics	Adipose Tissue (enzymology) Animals Apolipoproteins E (deficiency) Atherosclerosis (genetics, metabolism) Coronary Artery Disease (epidemiology, genetics, prevention & control) Genetic Predisposition to Disease Humans Lysophospholipids (metabolism, physiology) Mice Mice, Knockout Phosphatidate Phosphatase (deficiency, genetics, physiology) Phosphoric Diester Hydrolases (physiology) Plaque, Atherosclerotic (metabolism) Risk Sphingosine (analogs & derivatives, metabolism)

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