Diagnosis and monitoring of pregnancy in mice: correlations between maternal weight, fetal and placental mass and the maternal serum levels of progesterone, pregnancy-associated murine protein-2 and alpha-fetoprotein.

Abstract	Outbred Bom:NMRI mice were weighed daily for 18 days from observation of a vaginal plug. In a separate experiment, fetuses and placentae were weighed on each day of pregnancy. Pregnancy can be determined with 99% certainty on day 12 of gestation by the maternal body weight increase from day 1. The pregnancy-specific proteins alpha-fetoprotein (m-AFP) and pregnancy-associated murine protein-2 (PAMP-2), of fetal and placental origin respectively, were detectable on days 8 and 10 in the maternal circulation. Significant correlations were observed between m-AFP and fetal weight and PAMP-2 and placental weight. These markers may therefore be useful in the monitoring of fetal growth and placental growth respectively.
Authors	J Hau, H J Skovgaard Jensen
Journal	Laboratory animals (Lab Anim) Vol. 21 Issue 4 Pg. 306-10 (Oct 1987) ISSN: 0023-6772 [Print] England
PMID	2447327 (Publication Type: Journal Article)
Chemical References	Pregnancy Proteins alpha-Fetoproteins pregnancy-associated murine protein 2 Progesterone
Topics	Animals Body Weight Female Fetus (anatomy & histology) Mice (physiology) Monitoring, Physiologic (veterinary) Organ Size Placenta (anatomy & histology) Pregnancy Pregnancy Proteins (analysis) Pregnancy Tests (veterinary) Pregnancy, Animal (blood, physiology) Progesterone (blood) alpha-Fetoproteins (analysis)

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