Abstract |
Two human mesothelioma xenograft lines, BG and ES, serially passaged in athymic mice, were studied to determine the efficacy of alpha-interferon in this type of tumor. Treatment began after progressive tumor growth was established. Recombinant human alpha-interferon-2a ( Roferon- A) was given by s.c. injection, at a site distant from the tumor, at a dose of 2 x 10(5) IU 5 days per wk for 5 wk. Mild inhibitory activity was noted in both lines with interferon alone. cis-Diamminedichloroplatinum(II) (CDDP) (4 mg/kg) weekly x 5 was effective in line BG, while mitomycin C (1.5 mg/kg) weekly x 3 was effective in line ES. CDDP was not as effective in line ES. The moderate activity of CDDP in line BG and of mitomycin C in line ES was markedly increased by the addition of alpha-interferon. The combination of mitomycin C and alpha-interferon was as effective as mitomycin C and CDDP. No additional toxicity was noted by the addition of alpha-interferon. The combination of recombinant human alpha-interferon-2a and active chemotherapeutic agents is effective in mesothelioma xenografts.
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Authors | N T Sklarin, A P Chahinian, E J Feuer, L A Lahman, L Szrajer, J F Holland |
Journal | Cancer research
(Cancer Res)
Vol. 48
Issue 1
Pg. 64-7
(Jan 01 1988)
ISSN: 0008-5472 [Print] United States |
PMID | 2446742
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Mitomycins
- Mitomycin
- Interferons
- Cisplatin
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cisplatin
(administration & dosage)
- Drug Synergism
- Female
- Humans
- Interferons
(administration & dosage)
- Mesothelioma
(drug therapy)
- Mice
- Mice, Nude
- Mitomycin
- Mitomycins
(administration & dosage)
- Neoplasm Transplantation
- Transplantation, Heterologous
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