HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Heterogeneity of tumor vasculature and antiangiogenic intervention: insights from MR angiography and DCE-MRI.

AbstractPURPOSE:
Solid tumor vasculature is highly heterogeneous, which presents challenges to antiangiogenic intervention as well as the evaluation of its therapeutic efficacy. The aim of this study is to evaluate the spatial tumor vascular changes due to bevacizumab/paclitaxel therapy using a combination approach of MR angiography and DCE-MRI method.
EXPERIMENTAL DESIGN:
Tumor vasculature of MCF-7 breast tumor mouse xenografts was studied by a combination of MR angiography and DCE-MRI with albumin-Gd-DTPA. Tumor macroscopic vasculature was extracted from the early enhanced images. Tumor microvascular parameters were obtained from the pharmacokinetic modeling of the DCE-MRI data. A spatial analysis of the microvascular parameters based on the macroscopic vasculature was used to evaluate the changes of the heterogeneous vasculature induced by a 12 day bevacizumab/paclitaxel treatment in mice bearing MCF-7 breast tumor.
RESULTS:
Macroscopic vessels that feed the tumors were not affected by the bevacizumab/paclitaxel combination therapy. A higher portion of the tumors was within close proximity of these macroscopic vessels after the treatment, concomitant with tumor growth retardation. There was a significant decrease in microvascular permeability and vascular volume in the tumor regions near these vessels.
CONCLUSION:
Bevacizumab/paclitaxel combination therapy did not block the blood supply to the MCF-7 breast tumor. Such finding is consistent with the modest survival benefits of adding bevacizumab to current treatment regimens for some types of cancers.
AuthorsWenlian Zhu, Yoshinori Kato, Dmitri Artemov
JournalPloS one (PLoS One) Vol. 9 Issue 1 Pg. e86583 ( 2014) ISSN: 1932-6203 [Electronic] United States
PMID24466160 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Albumins
  • Antibodies, Monoclonal, Humanized
  • Contrast Media
  • albumin-(gadolinium-DTPA)
  • Bevacizumab
  • Gadolinium DTPA
  • Paclitaxel
Topics
  • Albumins (pharmacokinetics)
  • Animals
  • Antibodies, Monoclonal, Humanized (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bevacizumab
  • Breast Neoplasms (blood supply, drug therapy, pathology)
  • Contrast Media (pharmacokinetics)
  • Female
  • Gadolinium DTPA (pharmacokinetics)
  • Humans
  • Magnetic Resonance Angiography
  • Mice
  • Mice, SCID
  • Neovascularization, Pathologic (prevention & control)
  • Paclitaxel (administration & dosage)
  • Tissue Distribution
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: