Abstract | UNLABELLED: Animal studies have reported a cardioprotective effect for atrial natriuretic peptide ( ANP) or brain natriuretic peptide (BNP) administration in the setting of acute myocardial infarction (AMI). However, previous trials performed on AMI patients have reported differences in the cardiac function protection for ANP/BNP infusion, making it diffi cult to confirm the beneficial effect of natriuretic peptides. We performed a meta-analysis of all available trials to determine whether ANP/BNP infusion was effective in improving cardiac function. METHODS: We searched various databases including PubMed, EMBASE, Web of Knowledge, the Cochrane Library, and CKNI for studies related to ANP/BNP infusion in AMI. The major outcome was left ventricular ejection fraction (LVEF). RESULTS: Twenty trials (4 for ANP, 16 for BNP) with 1389 patients were included. There were no significant differences in patient characteristics between the ANP/BNP infusion and control groups at baseline. Pooled analysis showed that patients in the ANP/BNP infusion group had significantly higher LVEF than in the control during follow-up [Studies on ANP: weighted mean differences (WMD) 2.94%, 95% confidence interval (CI): 1.39%-4.50%, P = 0.0002; Studies on BNP: WMD 4.45%, 95%CI: 2.25%-6.65%, P < 0.0001]. CONCLUSIONS: The present meta-analysis suggested that ANP/BNP infusion might be effective in protecting left ventricular function in patients with AMI. ANP/BNP infusion may be an effective adjunctive therapy for cardiac function protection in AMI patients.
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Authors | Ting Lyu, Yichao Zhao, Tuo Zhang, Wen Zhou, Fan Yang, Heng Ge, Song Ding, Jun Pu, Ben He |
Journal | International heart journal
(Int Heart J)
Vol. 55
Issue 1
Pg. 8-16
( 2014)
ISSN: 1349-3299 [Electronic] Japan |
PMID | 24463927
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Natriuretic Agents
- Natriuretic Peptide, Brain
- Atrial Natriuretic Factor
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Topics |
- Animals
- Atrial Natriuretic Factor
(therapeutic use)
- Clinical Trials as Topic
- Humans
- Myocardial Infarction
(drug therapy)
- Natriuretic Agents
(therapeutic use)
- Natriuretic Peptide, Brain
(therapeutic use)
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