Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?

Abstract

Ovarian yolk sac tumors are highly malignant germ cell tumors that commonly occur in young women. The hepatoid yolk sac tumor is a variant form of yolk sac tumor in which there has been extensive tumor differentiation to early liver tissue. Hepatoid differentiation is traditionally considered to signify a poor prognosis. This review focuses on diagnostic criteria and establishes the optimal treatment for patients with hepatoid yolk sac tumor. Immunohistochemical stains are useful for distinguishing hepatoid yolk sac tumor from the other hepatoid-appearing tumors. With a multidisciplinary treatment approach using platinum-based regimens, the outcome is similar to those of any yolk sac tumor.

• Authors: Kristsanamon Rittiluechai, Rebecca Wilcox, Jennifer Lisle, Elise Everett, H James Wallace 3rd, Claire F Verschraegen
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 175 Pg. 25-9 (Apr 2014) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 24462393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Topics

• Carcinoma, Hepatocellular (diagnosis)
• Diagnosis, Differential
• Endodermal Sinus Tumor (pathology, therapy)
• Female
• Humans
• Liver
• Liver Neoplasms (diagnosis)
• Ovarian Neoplasms (pathology, therapy)
• Ovary (pathology)
• Prognosis