Abstract |
Mannitol is an osmotic diuretic agent useful in a variety of clinical conditions. This study is based on acid-base and electrolyte changes seen after the intravenous infusion of hypertonic mannitol for the prevention of cerebral edema. The study subjects were divided into 3 groups: for group A, an amount of 300-900 mL 15% mannitol was intravenously infused over the period of 60 to 90 minutes; for group B, 1,200-2,600 mL over 12 to 24 hours; and for group C, 3,200-4,900 mL over more than 24 hours. In group A, blood pH is increased from 7.43±0.07 to 7.46±0.04, and plasma HCO3 (-) from 25.3±2.1 to 28.9±2.9 mEq/L, but plasma K(+) is decreased from 4.3±0.6 to 3.7±0.8 mEq/L. In group B, blood pH is increased from 7.42±0.02 to 7.47±0.06, and plasma HCO3 (-) from 25.2±1.8 to 29.1±2.9 mEq/L, but plasma K(+) is decreased from 4.2±0.3 to 3.8±0.5 mEq/L. In group C, blood pH is increased from 7.41±0.01 to 7.52±0.04, and plasma HCO3 (-) from 24.9±1.2 to 27.7±2.5 mEq/L, but plasma K(+) is decreased from 4.2±0.1 to 3.9±0.2 mEq/L. These results showed that intravenous infusion of mannitol could induce metabolic alkalosis and hypokalemia, regardless of its dose. The mannitol induced metabolic alkalosis may be due to increased renal HCO3 (-) production.
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Authors | Kyung Pyo Kang, Sik Lee, Kyung Hoon Lee, Sung Kyew Kang |
Journal | Electrolyte & blood pressure : E & BP
(Electrolyte Blood Press)
Vol. 4
Issue 2
Pg. 61-5
(Nov 2006)
ISSN: 1738-5997 [Print] Korea (South) |
PMID | 24459488
(Publication Type: Journal Article)
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