Addicted to secrete - novel concepts and targets in cancer therapy.

Abstract

The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the UPR in cancer models. However, the UPR may not be the only druggable target of the SP. Moreover, recent studies have revealed other contributions of the SP to cancer development. This article does not intend to describe the well-established implication of UPR signaling pathways in cancer cell life and cell decision, but rather aims at defining the concept of 'tumor cell secretory addiction', from molecular, cellular, and therapeutic perspectives. Furthermore, the implication of UPR modulations in this context will be discussed.

• Authors: Nicolas Dejeans, Serge Manié, Claudio Hetz, Frédéric Bard, Ted Hupp, Patrizia Agostinis, Afshin Samali, Eric Chevet
• Journal: Trends in molecular medicine (Trends Mol Med) Vol. 20 Issue 5 Pg. 242-50 (May 2014) ISSN: 1471-499X [Electronic] England
• PMID: 24456621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Proteins

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Humans
• Neoplasms (drug therapy, genetics, metabolism)
• Proteins (antagonists & inhibitors, genetics, metabolism)
• Secretory Pathway (drug effects)
• Signal Transduction
• Unfolded Protein Response (drug effects)