Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.

Abstract

The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat's liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.

• Authors: T N Popova, A A Agarkov, A N Verevkin
• Journal: Acta naturae (Acta Naturae) Vol. 5 Issue 4 Pg. 118-22 (Oct 2013) ISSN: 2075-8251 [Print] Russia (Federation)
• PMID: 24455191 (Publication Type: Journal Article)