Abstract | OBJECTIVE: MATERIALS AND METHODS: Twenty-eight Sprague Dawley rats were used in this sudy. Rats were divided into four groups; a control group, a BV group, a 5-FU group and a BV+5-FU group. L1-2 laminectomies were performed on the rats. The medicated groups were treated with topical drug administration. After 6 weeks, the rats were sacrified and histologic sections prepared from the spines were examined and graded by a pathologist. Epidural fibrosis and fibroblast density were evaluated under light microscope. RESULTS: BV ( Avastin: Genentech, San Francisco, CA, USA) significantly reduced the density of the scar tissue undermining the laminas (p < 0.005). Monotherapy with 5-FU did not change the scar formation in the back (p = 0.317). Combination of 5-FU and BV was more effective on reducing the epidural fibrosis after laminectomy on rats (p < 0.001). CONCLUSIONS:
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Authors | U Ozkan, A Osun, A Samancioglu, S Ercan, U Firat, S Kemaloglu |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 18
Issue 1
Pg. 95-100
( 2014)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 24452949
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- Vascular Endothelial Growth Factor A
- Bevacizumab
- Fluorouracil
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Topics |
- Animals
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Bevacizumab
- Drug Therapy, Combination
- Epidural Space
(drug effects, pathology)
- Fibrosis
- Fluorouracil
(therapeutic use)
- Laminectomy
(adverse effects)
- Lumbar Vertebrae
(surgery)
- Male
- Postoperative Complications
(drug therapy)
- Rats, Sprague-Dawley
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
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