[Effects of iron ion additional introduction in radiation therapy of tumor-bearing animals].

Abstract

The gender differences of the transplantable glioma-35 growth were revealed in tumor-bearing rats. The effect of mineral iron containing water (ICW) as drinking water was studied during radiation therapy (RT) in tumor bearing male rats. It was shown that ICW used separately had a weak anti cancer effect. The ICW use after irradiation caused no significant changes in hematological reactions as compared with RT only. The mineral water administration before irradiation resulted in the reduction of the supercoiled DNA index on the 1st and 21st day after irradiation, as well as in monocytopeny and a definite decrease in the tumor volume on the 21st day of the experiment as compared with control, which is associated with the ferroptosis effect of ICW. It was established that the reaction peculiarities of the blood DNA structure index in irradiated rats at the early stage of glioma growth may serve an express marker of the efficiency of RT.

• Authors: S D Ivanov, A L Semenov, V M Mikhelson, E G Kovan'ko, V A Iamshanov
• Journal: Radiatsionnaia biologiia, radioecologiia (Radiats Biol Radioecol) 2013 May-Jun Vol. 53 Issue 3 Pg. 296-303 ISSN: 0869-8031 [Print] Russia (Federation)
• PMID: 24450211 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• Water
• Iron

Topics

• Animals
• DNA, Neoplasm (drug effects, radiation effects)
• Glioma (drug therapy, pathology, radiotherapy)
• Humans
• Iron (administration & dosage, chemistry)
• Male
• Neoplasms, Experimental (drug therapy, pathology, radiotherapy)
• Rats
• Water (chemistry)
• Xenograft Model Antitumor Assays