Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not histamine mobilization in the rat stomach.

Abstract

In chronic gastric fistula rats provided with a duodenal loop anastomosed to the jejunum (Roux-en-Y), maximal stimulation of acid secretion by continuous intravenous infusion of pentagastrin produced a 15-fold increase of gastric histidine decarboxylase activity. Intraduodenal instillation of 0.20 M HCl or 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) inhibited the maximal acid response to pentagastrin by 61% and hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl by 79% but did not suppress the pentagastrin-induced increase in enzyme activity. Hence, instillation of HCl and/or hyperosmolal PEG solution in the duodenum depresses the responsiveness of the parietal cells to pentagastrin without interfering with pentagastrin-induced activation of gastric histamine formation.

• Authors: S Emås, R Håkanson
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 22 Issue 7 Pg. 776-80 (Sep 1987) ISSN: 0036-5521 [Print] England
• PMID: 2445017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polyethylene Glycols
• Sodium Chloride
• Histidine Decarboxylase
• Pentagastrin
• Hydrochloric Acid

Topics

• Anastomosis, Roux-en-Y
• Animals
• Duodenum (drug effects)
• Gastric Acid (metabolism)
• Histamine Release (drug effects)
• Histidine Decarboxylase (pharmacokinetics)
• Hydrochloric Acid (administration & dosage)
• Jejunum (surgery)
• Male
• Osmolar Concentration
• Pentagastrin (pharmacology)
• Polyethylene Glycols (administration & dosage)
• Rats
• Rats, Inbred Strains
• Sodium Chloride (administration & dosage)