Intraduodenal instillation of acid and hyperosmolal solution suppresses pentagastrin-stimulated acid secretion but not histamine mobilization in the rat stomach.

In chronic gastric fistula rats provided with a duodenal loop anastomosed to the jejunum (Roux-en-Y), maximal stimulation of acid secretion by continuous intravenous infusion of pentagastrin produced a 15-fold increase of gastric histidine decarboxylase activity. Intraduodenal instillation of 0.20 M HCl or 1200 mOsm X kg-1 solution of polyethylene glycol (PEG) inhibited the maximal acid response to pentagastrin by 61% and hyperosmolal (1200 mOsm X kg-1 of PEG solution) 0.20 M HCl by 79% but did not suppress the pentagastrin-induced increase in enzyme activity. Hence, instillation of HCl and/or hyperosmolal PEG solution in the duodenum depresses the responsiveness of the parietal cells to pentagastrin without interfering with pentagastrin-induced activation of gastric histamine formation.
AuthorsS Emås, R Håkanson
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 22 Issue 7 Pg. 776-80 (Sep 1987) ISSN: 0036-5521 [Print] NORWAY
PMID2445017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Polyethylene Glycols
  • Sodium Chloride
  • Histidine Decarboxylase
  • Pentagastrin
  • Hydrochloric Acid
  • Anastomosis, Roux-en-Y
  • Animals
  • Duodenum (drug effects)
  • Gastric Acid (secretion)
  • Histamine Release (drug effects)
  • Histidine Decarboxylase (pharmacokinetics)
  • Hydrochloric Acid (administration & dosage)
  • Jejunum (surgery)
  • Male
  • Osmolar Concentration
  • Pentagastrin (pharmacology)
  • Polyethylene Glycols (administration & dosage)
  • Rats
  • Rats, Inbred Strains
  • Sodium Chloride (administration & dosage)

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