Abstract | BACKGROUND: AIM: METHODS: Adult outpatients with Los Angeles grade C or D esophagitis were allocated to open-label 40 mg IR-OME once a day for 8 weeks in a prospective, randomized, parallel design, single center study. Esophagogastroduodenoscopy (EGD) and validated self-report symptom questionnaires were completed at baseline and follow-up. Intention-to-treat and per-protocol analyses were performed. RESULTS: Ninety-two of 128 (72 %) eligible subjects participated [64 (70 %) male, mean age 58 (range 19-86), median BMI 29 (range 21-51), 58 C:34 D]. Overall, 81 (88 %) subjects healed [n = 70 (76 %)] or improved [n = 11 (12 %)] erosions. There was no significant difference (morning vs. night) in mucosal healing [81 vs. 71 %, (p = 0.44)] or symptom resolution [ heartburn (77 vs. 65 %, p = 0.12), acid regurgitation (82 vs. 73 %, p = 0.28)]. Prevalence of newly identified Barrett's esophagus was 14 % with half diagnosed only after treatment. CONCLUSIONS:
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Authors | Diana M Orbelo, Felicity T Enders, Yvonne Romero, Dawn L Francis, Sami R Achem, Tushar S Dabade, Michael D Crowell, Debra M Geno, Ramona S DeJesus, Vikneswaran Namasivayam, Steven C Adamson, Amindra S Arora, Andrew J Majka, Jeffrey A Alexander, Joseph A Murray, Matthew Lohse, Nancy N Diehl, Mary Fredericksen, Kee Wook Jung, Margaret S Houston, Angela E O'Neil, David A Katzka |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 60
Issue 1
Pg. 146-62
(Jan 2015)
ISSN: 1573-2568 [Electronic] United States |
PMID | 24448652
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Proton Pump Inhibitors
- omeprazole, sodium bicarbonate drug combination
- Sodium Bicarbonate
- Omeprazole
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Barrett Esophagus
(epidemiology)
- Comorbidity
- Drug Combinations
- Endoscopy, Digestive System
- Endoscopy, Gastrointestinal
- Esophagitis, Peptic
(drug therapy, epidemiology)
- Female
- Humans
- Intention to Treat Analysis
- Male
- Middle Aged
- Mucous Membrane
(pathology)
- Omeprazole
(administration & dosage)
- Prospective Studies
- Proton Pump Inhibitors
(administration & dosage)
- Sodium Bicarbonate
(administration & dosage)
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