Repair of tetralogy of Fallot in or beyond the fourth decade of life.

Abstract

OBJECTIVE:

Patients with tetralogy of Fallot (TOF) undergoing surgery in adulthood represent a challenge. We report our experience with such patients in or beyond the fourth decade of life.

DESIGN:

Retrospective cohort.

SETTING:

Multispeciality tertiary level referral center

PATIENTS:

Forty-one (age 30-52 years) with TOF undergoing surgery between January 2002 and March 2013. The hospital records of these patients were analyzed.

INTERVENTIONS:

None.

OUTCOME MEASURES:

Early and late morbidity and mortality, duration of mechanical ventilatory support, inotropic score, intensive care unit and hospital stay, and correlation with various parameters.

RESULTS:

Significant aortopulmonary collaterals were present in 28 patients; these were occluded in cardiac catheterization laboratory prior to repair. Median intraoperative right:left ventricular pressure ratio was 0.40 (range 0.2-0.8). Median inotropic score was 10 (range 5-30). Median duration of mechanical ventilation was 12 hours (range 6-48 hours). Preoperative oxygen saturation was negatively correlated with inotropic score (P = .001, r = -0.485), mechanical ventilatory support (P = .003, r = -0.460), intensive care unit stay (P = .004, r = -0.442), and hospital stay (P = .028, r = -353). Inotropic score was higher in patients with aortopulmonary collaterals (n = 28, P = .03), high preoperative hematocrit (n = 29, P = .029), and with right ventricular dysfunction (n = 6, P = .05). Patients with right ventricular outflow tract gradient >80 mm Hg (n = 19) had prolonged hospital stay (P = .002). Patients undergoing pure transatrial repair (n = 24) showed lower inotropic score (P = .045), less intensive care unit (P = .04), and hospital stay (P = .031). There were two early and two late deaths (one from trauma and one from unknown etiology). Median follow-up was 42 months. Thirty-one patients were in New York Heart Association class II and six were in class III.

CONCLUSION:

Repair of TOF in and beyond the fourth decade of life is feasible with acceptable results. Patients with high hematocrit, lower oxygen saturation, right ventricular dysfunction, aortopulmonary collaterals, and high preoperative right ventricular outflow tract gradients have a prolonged postoperative course.

• Authors: Sachin Talwar, Ajay Meena, Shiv Kumar Choudhary, Anita Saxena, Shyam Sunder Kothari, Rajnish Juneja, Balram Airan
• Journal: Congenital heart disease (Congenit Heart Dis) Vol. 9 Issue 5 Pg. 424-32 ( 2014) ISSN: 1747-0803 [Electronic] United States
• PMID: 24447400 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Topics

• Adult
• Age Factors
• Cardiac Surgical Procedures (adverse effects, mortality)
• Collateral Circulation
• Female
• Hemodynamics
• Humans
• India
• Length of Stay
• Male
• Middle Aged
• Postoperative Complications (physiopathology, therapy)
• Retrospective Studies
• Risk Factors
• Tertiary Care Centers
• Tetralogy of Fallot (complications, diagnosis, mortality, physiopathology, surgery)
• Time Factors
• Treatment Outcome
• Ventricular Dysfunction, Right (etiology, physiopathology)
• Ventricular Function, Left
• Ventricular Function, Right
• Ventricular Outflow Obstruction (etiology, physiopathology)