A targeting drug delivery system for ovarian carcinoma: transferrin modified lipid coated paclitaxel-loaded nanoparticles.

Abstract

The transferring modified lipid coated PLGA nanoparticles, as a targetable vector, were developed for the targeting delivery of anticancer drugs with paclitaxel (PTX) as a model drug to the ovarian carcinoma, which combines the advantages and avoids disadvantages of polymeric nanoparticles and liposomes in drug delivery. A transmission electron microscopy (TEM) confirmed the lipid coating on the polymeric core. Physicochemical characterizations of TFLPs, such as particle size, zeta potential, morphology, encapsulation efficiency, and in vitro PTX release, were also evaluated. In the cellular uptake study, the TFLPs were more efficiently endocytosed by the A2780 cells with high expression of transferrin receptors than HUVEC cells without the transferrin receptors. Furthermore, the anticancer efficacy of TFLPs on the tumor spheroids was stronger than that of lipid coated PLGA nanoparticles (LPs) and PLGA nanoparticles. In the in vivo study, the TFLPs showed the best inhibition effect of the tumor growth for the ovarian carcinoma-bearing mice. In brief, the TFLPs were proved to be an efficient targeting drug delivery system for ovarian carcinoma.

• Authors: R Li, Q Zhang, X-y Wang, X-g Chen, Y-x He, W-y Yang, X Yang
• Journal: Drug research (Drug Res (Stuttg)) Vol. 64 Issue 10 Pg. 541-7 (Oct 2014) ISSN: 2194-9387 [Electronic] Germany
• PMID: 24443309 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Antineoplastic Agents, Phytogenic
• Lipids
• Liposomes
• Transferrin
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• Paclitaxel

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, chemistry, metabolism)
• Carcinoma (drug therapy, metabolism, pathology)
• Cell Line, Tumor
• Chemistry, Pharmaceutical
• Drug Stability
• Endocytosis
• Female
• Human Umbilical Vein Endothelial Cells (drug effects, metabolism)
• Humans
• Lactic Acid (chemistry)
• Lipids (chemistry)
• Liposomes
• Mice, Inbred BALB C
• Mice, Nude
• Microscopy, Electron, Transmission
• Nanomedicine
• Nanoparticles
• Ovarian Neoplasms (drug therapy, metabolism, pathology)
• Paclitaxel (administration & dosage, chemistry, metabolism)
• Particle Size
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Solubility
• Surface Properties
• Technology, Pharmaceutical (methods)
• Time Factors
• Transferrin (chemistry, metabolism)
• Tumor Burden
• Xenograft Model Antitumor Assays