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Detection of toxic monofluoroacetate in Palicourea species.

Abstract
Numerous plant species worldwide including some Palicourea (Rubiaceae), Tanaecium (Bignoniaceae), and Amorimia (Malpighiaceae) species in Brazil cause sudden death and are known to contain monofluoroacetate (MFA). Two species of Palicourea, Palicourea aenofusca and Palicourea marcgravii, cause sudden death and are reported to contain MFA while other Palicourea species are reported to cause sudden death in livestock and are suspected to contain MFA due to the similarity in clinical signs. Using an HPLC-APCI-MS method to detect MFA, herbarium specimens representing 46 Palicourea taxa were screened for the presence of MFA. Additionally we screened five Psychotria taxa that are closely related to Palicourea species. Ten species of Palicourea were identified that contained MFA, two previously reported and eight newly reported here; these are closely related to each other, though some other related species did not contain MFA.
AuthorsDaniel Cook, Stephen T Lee, Charlotte M Taylor, Burgund Bassüner, Franklin Riet-Correa, James A Pfister, Dale R Gardner
JournalToxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 80 Pg. 9-16 (Mar 2014) ISSN: 1879-3150 [Electronic] England
PMID24440601 (Publication Type: Journal Article)
CopyrightPublished by Elsevier Ltd.
Chemical References
  • Fluoroacetates
  • Plant Extracts
  • fluoroacetic acid
Topics
  • Brazil
  • Chromatography, High Pressure Liquid
  • Fluoroacetates (chemistry, isolation & purification, toxicity)
  • Mass Spectrometry
  • Plant Extracts (analysis)
  • Plant Leaves (chemistry)
  • Rubiaceae (chemistry, classification)

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