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Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.

Abstract
The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
AuthorsAbraham H Abouzeid, Niravkumar R Patel, Vladimir P Torchilin
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 464 Issue 1-2 Pg. 178-84 (Apr 10 2014) ISSN: 1873-3476 [Electronic] Netherlands
PMID24440402 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Micelles
  • Phosphatidylethanolamines
  • dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine
  • Vitamin E
  • Polyethylene Glycols
  • Curcumin
  • Paclitaxel
Topics
  • Animals
  • Cell Line, Tumor
  • Curcumin (administration & dosage, metabolism)
  • Drug Resistance, Multiple (drug effects, physiology)
  • Drug Resistance, Neoplasm (drug effects, physiology)
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Micelles
  • Ovarian Neoplasms (drug therapy, metabolism)
  • Paclitaxel (administration & dosage, metabolism)
  • Phosphatidylethanolamines (administration & dosage)
  • Polyethylene Glycols (administration & dosage)
  • Vitamin E (administration & dosage, metabolism)
  • Xenograft Model Antitumor Assays (methods)

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