Abstract |
The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi- drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
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Authors | Abraham H Abouzeid, Niravkumar R Patel, Vladimir P Torchilin |
Journal | International journal of pharmaceutics
(Int J Pharm)
Vol. 464
Issue 1-2
Pg. 178-84
(Apr 10 2014)
ISSN: 1873-3476 [Electronic] Netherlands |
PMID | 24440402
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Micelles
- Phosphatidylethanolamines
- dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine
- Vitamin E
- Polyethylene Glycols
- Curcumin
- Paclitaxel
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Topics |
- Animals
- Cell Line, Tumor
- Curcumin
(administration & dosage, metabolism)
- Drug Resistance, Multiple
(drug effects, physiology)
- Drug Resistance, Neoplasm
(drug effects, physiology)
- Female
- Humans
- Mice
- Mice, Nude
- Micelles
- Ovarian Neoplasms
(drug therapy, metabolism)
- Paclitaxel
(administration & dosage, metabolism)
- Phosphatidylethanolamines
(administration & dosage)
- Polyethylene Glycols
(administration & dosage)
- Vitamin E
(administration & dosage, metabolism)
- Xenograft Model Antitumor Assays
(methods)
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