Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A₁chieve study.

Abstract

BACKGROUND:

The effectiveness and safety of initiating biphasic insulin aspart 30 in patients who were poorly controlled on oral glucose-lowering drugs were studied in randomized controlled trials, while results from clinical practice remain limited. This subgroup analysis was to provide such findings from a large-scale non-interventional study.

METHODS:

A1chieve was a multinational, prospective, open-label, non-interventional, 24-week study in patients with type 2 diabetes initiating insulin analogues in 28 countries across Asia, Africa, Europe, and Latin America. After physician had taken the decision to use this insulin, any patient with type 2 diabetes who was not treated with or who had started the study insulin within 4 weeks before inclusion was eligible. Patients were treated with study insulin alone or in combination with oral glucose-lowering drugs. Data on adverse drug reactions, hypoglycemia and glycemic control were collected at baseline, week 12 and 24. This is a report of a Chinese subgroup analysis from the A1chieve study.

RESULTS:

Totally, 4 100 patients constituted this subgroup. No serious adverse drug reactions were reported. Rates of total, major, nocturnal hypoglycemic events (events/patient per year) were 1.47, 0.10, 0.31 at baseline and 1.35, 0.00, 0.22 at week 24, respectively. Glycemic control was improved as measured by hemoglobin A1c (mean 9.3% to 7.0%, reduction -2.3%), fasting plasma glucose (mean 10.2 to 6.8 mmol/L, reduction -3.5 mmol/L) and postprandial plasma glucose (mean 14.4 to 8.8 mmol/L, reduction -5.6 mmol/L), all P < 0.001. Change in mean body weight was +0.3 kg (P < 0.001).

CONCLUSION:

In this subgroup analysis of the A1chieve study, biphasic insulin aspart 30 improved glycemic control with low risk of hypoglycemia.

• Authors: Liming Chen, Xiaoyan Xing, Minxiang Lei, Jie Liu, Yongquan Shi, Pengqiu Li, Guijun Qin, Chengjiang Li, Yukun Li, Qing Wang, Tianshu Gao, Ling Hu, Yangwei Wang, Wenying Yang
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 127 Issue 2 Pg. 208-12 ( 2014) ISSN: 2542-5641 [Electronic] China
• PMID: 24438605 (Publication Type: Journal Article)

Chemical References

• Biphasic Insulins
• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• insulin aspart, insulin aspart protamine drug combination 30:70
• Insulin, Isophane
• Insulin Aspart

Topics

• Administration, Oral
• Adult
• Aged
• Biphasic Insulins (administration & dosage, adverse effects, therapeutic use)
• Blood Glucose (drug effects)
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin Aspart (administration & dosage, adverse effects, therapeutic use)
• Insulin, Isophane (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged
• Prospective Studies