Abstract | PURPOSE: METHODS: This randomized single-center study involved 105 patients (53 with and 52 without silodosin). Silodosin was postoperatively administered, daily, for 6 months (8 mg/day). Urinary symptoms and pressure flow were evaluated preoperatively and postoperatively at 1, 3, 6, and 12 months. RESULTS: At 12 months, interstitial (125)I implantation had induced a significant decrease in prostate volume (28.3 ± 11.1-20.5 ± 8.1 g in the silodosin group and 26.1 ± 9.7-17.7 ± 4.9 g in the controls) and the prostate-specific antigen level (7.1 ± 3.6-1.4 ± 1.7 ng/mL in the silodosin group and 8.1 ± 4.3-1.3 ± 1.2 ng/mL in the controls). Significant improvements in the international prostate symptom voiding subscores at 6 months and quality of life at 3 months were observed in those receiving silodosin. The pressure flow studies demonstrated that silodosin had significantly enlarged the bladder capacity when the first non-voiding contraction was seen at 3 and 12 months (3M: 127.1 ± 74.8 vs. 118.2 ± 83.9 mL, p = 0.001; 12M: 123.7 ± 79.3 vs. 100.3 ± 73.4 mL, p = 0.01); however, there were no improvements in the bladder outlet obstruction index (BOOI) or urinary flow. CONCLUSIONS:
Silodosin temporarily improved LUTS, but did not improve the BOOI after (125)I implantation in the prostate.
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Authors | Nobutaka Shimizu, Takafumi Minami, Koichi Sugimoto, Yoshitaka Saito, Yutaka Yamamoto, Taiji Hayashi, Hidenori Tsuji, Masahiro Nozawa, Kazuhiro Yoshimura, Tokumi Ishii, Hirotsugu Uemura, Kiyoshi Nakamatsu |
Journal | World journal of urology
(World J Urol)
Vol. 32
Issue 6
Pg. 1423-32
(Dec 2014)
ISSN: 1433-8726 [Electronic] Germany |
PMID | 24435207
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Indoles
- silodosin
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
(therapeutic use)
- Aged
- Brachytherapy
(adverse effects)
- Humans
- Indoles
(therapeutic use)
- Lower Urinary Tract Symptoms
(drug therapy, etiology, physiopathology)
- Male
- Middle Aged
- Prostatic Neoplasms
(pathology, physiopathology, radiotherapy)
- Quality of Life
- Treatment Outcome
- Urinary Bladder Neck Obstruction
(drug therapy, etiology, physiopathology)
- Urodynamics
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