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New molecule for mobilizing marrow stem cells.

Abstract
In this issue of Blood, Zhang et al describe an exciting new small-molecule antagonist of CXCL12-CXCR4 binding with a potent ability to mobilize hematopoietic stem cells (HSCs). Further clinical development of this new drug,Me6TREN, may have broad applications in stem-cell mobilization for cancer and in regenerative medicine.
AuthorsSakura Hosoba, Edmund K Waller
JournalBlood (Blood) Vol. 123 Issue 3 Pg. 310-1 (Jan 16 2014) ISSN: 1528-0020 [Electronic] United States
PMID24434996 (Publication Type: Comment, Journal Article)
Chemical References
  • Ethylamines
  • tris(2-(dimethylamino)ethyl)amine
Topics
  • Animals
  • Ethylamines (pharmacology)
  • Gene Expression Regulation
  • Hematopoietic Stem Cell Mobilization (methods)
  • Hematopoietic Stem Cells (cytology)
  • Humans

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