[Pharmacological studies on Y-8894 (VI). The effect on monoamine uptake and turnover in mouse brain].

Abstract	The effect of Y-8894 (+/-) 2-[[o-(2-thenyl)phenoxy]methyl] morpholine maleate, which has been shown to improve experimentally induced learning and memory deficits, on cerebral monoamine uptake and turnover was studied in the mouse. The following results were obtained: 1) It inhibited in vitro norepinephrine (NE) uptake to the mouse cerebral synaptosomal fractions about 800 and 1250 times more potently than it did those of dopamine (DA) and serotonin (5-HT), respectively. 2) It dose-dependently inhibited in vivo NE uptake, but not DA or 5-HT uptake. 3) It reduced the accumulation of the NE metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), increased that of the 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and had no effect on that of the DA metabolite, homovanillic acid (HVA). These effects were compared with those of imipramine, calcium hopantenate (Ca-hopantenate) and dihydroergotoxine. Y-8894 appeared to act by stimulating the noradrenergic receptor, and it acts to a lesser extent by blocking the serotonergic receptor in the brain.
Authors	M Setoguchi, S Takehara, M Sakamori, K Anami, Y Maruyama
Journal	Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 90 Issue 1 Pg. 41-9 (Jul 1987) ISSN: 0015-5691 [Print] Japan
PMID	2443434 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References	Biogenic Amines Central Nervous System Stimulants Morpholines Dihydroergotoxine pantogab Pantothenic Acid Serotonin Methoxyhydroxyphenylglycol Hydroxyindoleacetic Acid gamma-Aminobutyric Acid sufoxazine Imipramine Dopamine Norepinephrine Homovanillic Acid
Topics	Animals Biogenic Amines (metabolism) Brain (metabolism) Central Nervous System Stimulants (pharmacology) Dihydroergotoxine (pharmacology) Dopamine (metabolism) Homovanillic Acid (metabolism) Hydroxyindoleacetic Acid (metabolism) Imipramine (pharmacology) Male Methoxyhydroxyphenylglycol (metabolism) Mice Morpholines (pharmacology) Norepinephrine (metabolism) Pantothenic Acid (analogs & derivatives, pharmacology) Serotonin (metabolism) gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)

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