HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

CARMA: CARM1 methylation of SWI/SNF in breast cancer.

Abstract
In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin remodeling/tumor suppressor complex. This modification facilitates the targeting of BAF155 to genes of the c-Myc pathway and enhances breast cancer progression and metastasis.
AuthorsXiaofeng Wang, Charles W M Roberts
JournalCancer cell (Cancer Cell) Vol. 25 Issue 1 Pg. 3-4 (Jan 13 2014) ISSN: 1878-3686 [Electronic] United States
PMID24434203 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • SMARCC1 protein, human
  • Smarcc1 protein, mouse
  • Transcription Factors
  • Protein-Arginine N-Methyltransferases
  • coactivator-associated arginine methyltransferase 1
Topics
  • Animals
  • Breast Neoplasms (metabolism)
  • Female
  • Gene Expression Regulation, Neoplastic (physiology)
  • Humans
  • Protein-Arginine N-Methyltransferases (metabolism)
  • Transcription Factors (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: