Abstract | PURPOSE: METHODS: Data sources included electronic databases, personal communication, and back tracing of references in pertinent studies. These were prospective and retrospective human studies presenting original data for participants with convulsive benzodiazepine-resistant status epilepticus. Interventions were intravenous lacosamide, levetiracetam, phenobarbital, phenytoin and valproate. Outcome measured is clinically detectable cessation of seizure activity. Level-of-evidence was assessed according to Oxford Centre of Evidence-Based Medicine and The Cochrane Collaboration's Tool for Assessment of Risk. Twenty seven studies (798 cases of convulsive status epilepticus) were identified and 22 included in a meta-analysis. Random-effects analysis of dichotomous outcome of a single group estimate (proportion), with inverse variance weighting, was implemented. Several sources of clinical and methodological heterogeneity were identified. RESULTS: CONCLUSION:
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Authors | Zeid Yasiry, Simon D Shorvon |
Journal | Seizure
(Seizure)
Vol. 23
Issue 3
Pg. 167-74
(Mar 2014)
ISSN: 1532-2688 [Electronic] England |
PMID | 24433665
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2013 British Epilepsy Association. All rights reserved. |
Chemical References |
- Anticonvulsants
- Benzodiazepines
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Topics |
- Anticonvulsants
(therapeutic use)
- Benzodiazepines
(adverse effects)
- Databases, Factual
(statistics & numerical data)
- Humans
- Status Epilepticus
(drug therapy)
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