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Differentiation- and apoptosis-inducing activities of rice bran extracts in a human colon cancer cell line.

Abstract
Rice bran water extract (RBWE) and ethanol extract (RBEE) at 1.0 mg/ml markedly inhibited the proliferation of LS174T human colon cancer cells. RBEE but not RBWE induced apoptosis. RBWE promoted the production of intestinal mucin (MUC2). Real-time RT-PCR demonstrated that RBWE up-regulated the expression of MUC2 and sucrase-isomaltase complex (a differentiation marker of colon cancer cells), and attenuated that of proliferating cell nuclear antigen at the mRNA level in a dose-dependent manner. These findings suggested that RBWE suppress the proliferation of colon cancer cells by inducting differentiation not apoptosis.
AuthorsAkiko Takashima, Masanobu Ohtomo, Tsugio Kikuchi, Jun Iwashita, Tatsuya Abe, Keishi Hata
JournalJournal of food science and technology (J Food Sci Technol) Vol. 50 Issue 3 Pg. 595-9 (Jun 2013) ISSN: 0022-1155 [Print] India
PMID24425959 (Publication Type: Journal Article)

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