Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats.

Abstract

Scutellarin had protective effects against neuronal injury, however, there are few studies on the protective effect of scutellarein, which is the main metabolite of scutellarin in vivo. This study investigated whether the neural injury by ischemia/reperfusion would be influenced by different doses of scutellarin and scutellarein. Male Wistar rats were orally administered with scutellarin and scutellarein at the doses of 0.09, 0.17, 0.35, 0.70, 1.40 mmol/kg, respectively; then after six consecutive days, they were subjected to global ischemia by occlusion of the bilateral common carotid arteries (BCCAO). After reperfusion for about 21 h, neurological and histological examinations were performed. The present results showed that scutellarein attenuated neuronal cell damage, reduced cerebral water content, regulated the expression of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), γ-aminobutyric acid (GABA) and taurine (Tau), and improved the Ca(2+)-ATPase and Na(+),K(+)-ATPase activity. Meanwhile, significant difference was found among various doses of scutellarin and scutellarein. Our studies indicated that scutellarin and scutellarein could improve neuronal injury, and scutellarein had better protective effect than scutellarin in rat cerebral ischemia.

• Authors: Hao Tang, Yuping Tang, Nianguang Li, Qianping Shi, Jianming Guo, Erxin Shang, Jin-ao Duan
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 118 Pg. 51-9 (Mar 2014) ISSN: 1873-5177 [Electronic] United States
• PMID: 24423938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Amino Acids
• Antioxidants
• Glucuronates
• Neuroprotective Agents
• scutellarin
• Nimodipine
• Apigenin
• Sodium
• Calcium-Transporting ATPases
• Sodium-Potassium-Exchanging ATPase
• scutellarein
• Potassium
• Calcium

Topics

• Amino Acids (metabolism)
• Animals
• Antioxidants (administration & dosage, pharmacology)
• Apigenin (administration & dosage, pharmacology)
• Brain (drug effects, metabolism)
• Brain Injuries (metabolism, pathology, prevention & control)
• Brain Ischemia (drug therapy, metabolism, pathology)
• CA1 Region, Hippocampal (drug effects, pathology)
• Calcium (metabolism)
• Calcium-Transporting ATPases (metabolism)
• Glucuronates (administration & dosage, pharmacology)
• Learning (drug effects)
• Male
• Memory (drug effects)
• Neuroprotective Agents (administration & dosage, pharmacology)
• Nimodipine (pharmacology)
• Potassium (metabolism)
• Rats
• Rats, Wistar
• Reperfusion Injury (metabolism, pathology, prevention & control)
• Sodium (metabolism)
• Sodium-Potassium-Exchanging ATPase (metabolism)